With the advance of precision medicine, the availability of tumor tissue for molecular analysis has become a limiting factor.This is particularly the case for bone here metastases which are frequently occurring in cancer types such as prostate cancer.Due to the necessary decalcification process it was long thought that transcriptome analysis will n
Abstract The bactericidal function of neutrophils is dependent on a myriad of intrinsic and extrinsic stimuli.Using systems immunology approaches we identify microbiome- and infection-induced changes in neutrophils.We focus on investigating the Prenylcysteine oxidase 1 like (Pcyox1l) protein function.Murine and human Pcyox1l proteins share ninety f
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies.Here, we developed a large-scale fluorescence polarization (FP) methodology that was able to characterize interactions between SH2 domains and ErbB receptor phos
The structural flexibility, nonlinear friction, and backlash are the major factors limiting the control performance revlon colorstay lip liner plum of precision transmission systems.If uncompensated, these factors compromise the positioning and tracking accuracy of precision transmission systems and even cause limit cycles and oscillation.In this a
The unsteady flow and heat transfer of a viscous incompressible, electrically conducting dusty fluid past vertical plate under the influence of a transverse magnetic field is studied with a view to examine the combined effects of suction, heat absorption and ramped wall temperature.The temperature of the wall is assumed to have a temporarily ramped